Assessment of Cholinergic and Cognitive Function Using Pharmacologic ASL-Perfusion MRI
Status:
Completed
Trial end date:
2013-01-01
Target enrollment:
Participant gender:
Summary
This research study will look at how medications affect the pattern of blood flow in the
brain. This study will use a special type of MRI (magnetic resonance imaging) scan called
perfusion MRI to make measurements of cerebral (brain) blood flow. The medications we will
use in this study are scopolamine (commonly used to treat motion sickness), mecamylamine
(used to treat high blood pressure), and donepezil (used to treat memory loss). Cognitive
testing will also be obtained, and correlated with the blood flow patterns in the brain.
Phase:
N/A
Details
Lead Sponsor:
Hebrew Rehabilitation Center, Boston Hebrew SeniorLife