Assessment of Airway Responsiveness and Treatment Efficacy in Asthmatics
Status:
Unknown status
Trial end date:
2016-05-01
Target enrollment:
Participant gender:
Summary
Bronchial asthma is a common chronic respiratory disease. Patients usually manifest variable
symptoms (such as short of breath, chest tightness, cough, etc.) and variable airflow
limitation and often associated with airway hyper-responsiveness and airway inflammation.
About 1-18% of the global population suffered from the disease, causing huge economic burden
for patients and countries. Airway reactivity measurement is an important way of diagnosis of
asthma. Methacholine (Mch) bronchial provocation test(BPT) is the "gold standard" for the
determination of airway reactivity, and other measuring methods(like adenosine
monophosphate(AMP)-BPT, leukotriene D4(LTD4)-BPT, Astograph-BPT, etc.) were also brought into
hot research fields. The investigators' purposes were to compare different kinds of
methodologies(Mch,AMP,LTD4-BPT, Astograph-BPT) assessing airway responsiveness and to
investigate treatment efficacy of budesonide /formoterol in asthmatics.