Overview

Assessing the Role of "Statin" Therapy and Perioperative Inflammatory Response in Patients Undergoing Major Orthopedic Surgery

Status:
Completed

Trial end date:
2016-03-01

Target enrollment:

Participant gender:

Summary

The purpose of the present study is to quantify the degree of modulation, if any, in the perioperative inflammatory response associated with statins use. Specifically, we hypothesize that: In a population of patients undergoing elective orthopedic spine surgery, administration of a specific statin (Simvastatin, Zocor®, Merck Pharmaceuticals), will be associated with a decrease in perioperative inflammatory markers when compared to patients not taking statins

Phase:

Phase 4

Details

Lead Sponsor:

Mayo Clinic

Treatments:

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Simvastatin