Overview

Assessing the Effect of Multiple Doses of Zibotentan on the Pharmacokinetics of Single Doses of Combined Oral Contraceptives in Healthy Female Participants of Non-childbearing Potential

Status:
Not yet recruiting
Trial end date:
2022-12-26
Target enrollment:
0
Participant gender:
Female
Summary
A study to assess the Pharmacokinetics (PK) of combined oral ethinyl estradiol (EE) and levonorgestrel (LNG) in healthy female participants of non-child-bearing potential, when administered alone and in combination with multiple oral doses of zibotentan.
Phase:
Phase 1
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
AstraZeneca
Collaborator:
Parexel
Criteria
Inclusion Criteria:

- Provision of signed and dated, written informed consent prior to any study specific
procedures.

- Capable of giving signed informed consent which includes compliance with the
requirements and restrictions listed in the protocol.

- Healthy female participants aged 35 to 75 years (inclusive) at Day -1 with suitable
veins for cannulation or repeated venipuncture.

- Females must have a negative pregnancy test at screening and within 24 hours prior to
dosing with EE/LNG on Day 1 and Day 15, must not be lactating and must be of non
childbearing potential, confirmed at screening by fulfilling one of the following
criteria:

(i) Postmenopausal defined as amenorrhea for at least 12 months or more following
cessation of all exogenous hormonal treatments and follicle-stimulating hormone (FSH)
levels in the postmenopausal range [FSH > 40 mIU/mL].

(ii) Documentation of irreversible surgical sterilization by hysterectomy, bilateral
oophorectomy or bilateral salpingectomy but not tubal ligation.

- Have a body mass index (BMI) between 18.5 and 35 kg/m2 inclusive at Day -1.

Exclusion Criteria:

- History of any clinically significant disease or disorder which, in the opinion of the
investigator, may either put the participant at risk because of participation in the
study, or influence the results or the participant's ability to participate in the
study. Clinically significant diseases or disorders also include, but are not limited
to:

(i) Undiagnosed abnormal uterine bleeding, (ii) Current diagnosis of, or history of
breast cancer, which may be hormone sensitive, (iii) Liver tumors, benign or
malignant, or liver disease. Acute viral hepatitis, or severe (decompensated)
cirrhosis or use of hepatitis C drug combinations containing
ombitasvir/paritaprevir/ritonavir, with or without dasabuvir, due to the potential for
alanine aminotransferase (ALT) elevations.

- Sex hormone therapy within 1 month before study.

- Current diagnosis or history of arterial or venous thrombosis (eg, deep vein
thrombosis (DVT), pulmonary embolism (PE)), or known heredity risk factors (eg,
activated protein C resistance), or coronary artery disease.

- Have inherited or acquired hypercoagulopathy.

- Participants treated with strong or moderate Cytochrome P450 3A4 (CYP3A4) inhibitors
or inducers within 3 months or longer (5 half-lives) prior to first administration of
IMP in this study.

- History or presence of gastrointestinal, hepatic or renal disease, or any other
condition known to interfere with absorption, distribution, metabolism, or excretion
of drugs.

- Any laboratory values with the following deviations:

(i) Alanine aminotransferase > Upper limit of normal (ULN) (ii) Aspartate
aminotransferase > ULN (iii) estimated glomerular filtration rate (eGFR) < 60
mL/min/1.73 m2 (iv) Creatinine > 1.5 ULN (v) White blood cell count < 3.5 x 109/L (vi)
Hemoglobin < lower limit of normal (LLN)

- Prolonged QT interval (QTcF > 470 ms) on ECG at check in into the clinical unit on Day
1 of Treatment Period 1, known congenital long QT syndrome or history of QT
prolongation associated with other medications.

- History of severe allergy/hypersensitivity or ongoing clinically important
allergy/hypersensitivity, as judged by the investigator or history of hypersensitivity
to drugs with a similar chemical structure or class to zibotentan.

- Participants who have received zibotentan within 1 month prior to Day 1 dosing.

- Any of the following signs or confirmation of COVID-19 infection:

(i) Positive COVID-19 test result on check in into the clinical unit on Day -1 and on
Day 14.

(ii) Clinical signs and symptoms consistent with COVID-19 (eg, fever, dry cough, dyspnoea,
sore throat, and fatigue) on check in into the clinical unit on Day 1.

(iii) Previously hospitalized with COVID-19 infection within the last 3 months prior to the
screening visit.