Aspirin for the Enhancement of Trophoblastic Invasion in Women With Abnormal Uterine Artery Doppler at 11-14 Weeks of Gestation

• Status: Completed
• Trial end date: 2015-04-01
• Target enrollment: 0
• Participant gender: Female

Summary

To establish wether a prophylactic intervention from first trimester with low-dose of aspirin improves trophoblastic invasion evaluated at third trimester in women defined as high-risk by abnormal uterine artery Doppler at first trimester

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sara Varea
• Treatments: Aspirin

Criteria

Inclusion Criteria:

• Patients over 18 years old attending for routine ultrasound at first trimester of pregnancy between 11 and 14 weeks of gestation (Crown-to rump length 45-48mm)

• Single gestation

• Mean pulsatility index of the uterine arteries above the 95th percentile for our population

Exclusion Criteria:

• Pre-existing hypertension, renal or cardiovascular disease

• previous history of pre-eclampsia

• Pregestational diabetes

• Systemic lupus Erythematosus

• Gastric ulcer

• Acetylsalicylic acid or lactose hypersensitivity

• Bleeding disorders

• Fetal disorders (including chromosomal abnormalities)

• Administration of low molecular weight heparin

• Concomitant treatment with aspirin