Aspirin and Plavix Following Coronary Artery Bypass Grafting

• Status: Terminated
• Trial end date: 2014-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The design of the study will be randomized, double blind trial, which will examine the effects of addition of clopidogrel to current guideline recommended background therapy on lowering the incidence of graft stenosis after coronary artery bypass grafting compared to placebo.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ahmad Slim
• Collaborator: Bristol-Myers Squibb
• Treatments: Aspirin; Clopidogrel; Ticlopidine

Criteria

Inclusion Criteria:

• Patients undergoing coronary artery bypass grafting, with or without cardiopulmonary bypass

• Age ≥ 18

Exclusion Criteria:

• Left ventricle ejection fraction <30%

• Emergency surgery

• Valve surgery

• Redo CABG

• Postoperative cardiogenic shock for more than 48 hours

• Postoperative bleeding or cardiac tamponade

• More than 24 hours postoperative intubation course

• Requirement of postoperative anticoagulation

• Serum creatinine >1.4

• Contraindication to use of postoperative coronary CT scan

• Allergy or contraindication to aspirin or clopidogrel

• Inability to provide informed consent

• Pregnant or breast feeding females