Aspirin Attenuates Inflammation in Human Cerebral Aneurysms
Status:
Completed
Trial end date:
2014-08-01
Target enrollment:
Participant gender:
Summary
Hypothesis: aspirin attenuates inflammation in cerebral aneurysms and hence reduces the
incidence of rupture. This effect can be monitored using the signal generated by macrophages
(inflammatory biomarker) in ferumoxytol-enhanced MRI.
Study aims:
1. Determine if daily aspirin intake (for three months) would obliterate/reduce
ferumoxytol-enhanced MRI signal changes generated by macrophages in cerebral aneurysm wall.
Fifteen patients with cerebral aneurysms > 7 mm will be selected to enroll in this pilot
study. 10 patients will be imaged at base line with ferumoxytol-enhanced MRI. Following that,
they will take aspirin 81 mg daily and then re-imaged again at three months. This group will
be compared to a control group of 5 patients where they will have the imagings studies
performed at base line and at three months but will NOT take aspirin.