Ascorbic Acid Versus Diode Laser in the Treatment of Gingival Hyperpigmentation

• Status: Completed
• Trial end date: 2016-09-10
• Target enrollment: 0
• Participant gender: All

Summary

Vitamin C affect the melanocytes function not the number while diode laser cause melanocytes destruction. Although diode laser and vitamin C have proved their effectiveness in depigmentation in previous studies, there are no published studies compared the effect of diode laser and vitamin C on melanocytes and melanosomes clinically and histologically.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ain Shams University
• Treatments: Ascorbic Acid

Criteria

Inclusion Criteria:

• Male and female patients with age ranging from 18 years old to 40 years old.

• Bilaterally symmetric gingival hyperpigmentation on the maxillary and mandibular labial keratinized gingiva between canines.

• Patients free from any systemic diseases as evidenced by the health questionnaire, using modified Cornell medical index (Pendleton et al., 2004).

• Patients with thick gingival biotype ≥ 3 mm.

Exclusion Criteria:

• Presence of local condition that may cause gingival hyperpigmentation (traumatized epithelium caused by defective fixed prosthesis or restoration).

• Smokers.

• Pregnant or lactating females.

• Patients with poor oral hygiene, incompliance to treatment and persistence gingival inflammation after phase I periodontal therapy.

• Clinically diagnosed periodontitis (attachment and bone loss, presence of periodontal pockets, gingival recession and tooth mobility).

• Previous treatment to pigmentation.

• Patients taking supplementary vitamin C for any reason.

• Known sensitivity to ascorbic acid or any of its derivatives.

• Patients taking any drug that may cause gingival pigmentation.