Arthroplasty Inflammation Prophylaxis With Celecoxib
Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
This double blinded, placebo controlled, study seeks to determine the efficacy of
preoperative anti-inflammatory therapy on the reduction of postoperative pain in knee
arthroplasty surgery. Pre-emptive use of NSAIDS has demonstrated only modest reduction in
post-operative pain in previous studies. However, the short duration of dosing in those
studies did not capitalized on the anti-inflammatory properties of NSAIDS. Short-term use of
NSAIDS only provides pain relief and does not address inflammation. Traditional NSAIDS cannot
be used preoperatively due to platelet effects. Celecoxib, however, is both an analgesic and
anti-inflammatory, but does not interfere with bleeding. It can therefore be safely used
before surgery. This study hypothesizes that the use of celecoxib for seven days
preoperatively reduces postoperative inflammation and consequently pain. A detailed Medline
search has not identified any studies into the preoperative use of an NSAID at a dosing level
that achieves anti-inflammatory effects.If effective in reducing postoperative pain, this
research could lead to a new understanding of the role inflammation plays in orthopedic
procedures and other elective procedures and thus improve patient outcomes in the future.