Arterial Pressure and Stress-Dose Steroids in Cardiac Arrest.
Status:
Not yet recruiting
Trial end date:
2022-12-01
Target enrollment:
Participant gender:
Summary
Early stress-dose steroids are of uncertain efficacy in cardiac arrest. The current authors
plan to conduct a pertinent mediation analysis using prospectively collected data from 2
prior randomized clinical trials of in-hospital cardiac arrest. These trials reported
positive results on the vasopressin-steroids-epinephrine (VSE) combination. The current
analysis is aimed at identifying mediators of the benefit associated with VSE, potentially
attributable to its stress-dose steroid subcomponent. Tested mediators will include arterial
pressure in the early postresuscitation period (primary), and arterial blood lactate in the
early postresuscitation period and renal failure free days (secondary).