Arterial Imaging of Inflammation and Resolution After Endovascular Surgery

• Status: Completed
• Trial end date: 2019-09-03
• Target enrollment: 0
• Participant gender: All

Summary

This study evaluates the local inflammatory and resolution response of patients undergoing peripheral vascular intervention like an angioplasty of the superficial femoral artery (SFA) or popliteal artery, or stenting of the iliac artery or SFA, through the use of Positron emission tomography-magnetic resonance imaging (PET/MRI). PET/MRI will be performed prior to intervention, one day and one week after intervention.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of California, San Francisco
• Treatments: Fluorodeoxyglucose F18

Criteria

Inclusion Criteria:

• Over the age of 40,

• With resting or exercise ABI <0.9, TBI <0.6

• Have claudication or limb threatening ischemia & planning to undergo a percutaneous angioplasty of SFA or popliteal artery, or stenting of the iliac artery or SFA.

Exclusion Criteria:

• Evidence of active infection

• Hypersensitivity or allergy to contrast agents

• Chronic liver disease, renal disease (GFR< 30) or chronic inflammatory disorders

• Insulin dependent diabetes

• Presence of metal within subject's body, pacemakers, or defibrillators

• BMI < 20 or >35

• Recent other major surgery or illness within 30 days

• Use of immunosuppressive medications or steroids

• History of organ transplantation

• Pregnancy, or plans to become pregnant, or lactating