Artemether-lumefantrine for Treatment of P. Falciparum Malaria in Brazil
Status:
Completed
Trial end date:
2016-12-01
Target enrollment:
Participant gender:
Summary
This is an in vivo evaluation of drug efficacy performed in Cruzeiro do Sul, in the state of
Acre, Brazil. A total of 81 participants ≥5 years old with parasitological confirmation of P.
falciparum monoinfection will be treated under supervision with artemether-lumefantrine for
three days, with doses according to the Brazilian guidelines for malaria control. The
clinical and parasitological parameters will be monitored for a 28-day follow-up period to
evaluate the efficacy of the combination therapy. A blood sample will be collected on filter
paper on the first day and on the day of suspected failure to try to differentiate the
parasite genotypes using techniques based on polymerase chain reactions. The results of this
efficacy evaluation on the drug combination will help the Brazilian Ministry of Health to
evaluate the national policy for treatment of malaria caused by P. falciparum.
Phase:
N/A
Details
Lead Sponsor:
Centers for Disease Control and Prevention
Collaborators:
Evandro Chagas National Institute of Infectious Disease Ministry of Health, Brazil Secretaria Estadual de Saúde do Acre
Treatments:
Artemether Artemether-lumefantrine combination Artemether, Lumefantrine Drug Combination Artemisinins Lumefantrine