Aripiprazole to Reduce Cocaine Relapse

• Status: Completed
• Trial end date: 2012-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Despite the many behavioral and cognitive treatment therapies that exist for cocaine addiction, individuals who complete cocaine abuse treatment are still at high risk for relapsing. Aripiprazole, a medication that is currently used to treat schizophrenia, may be useful in preventing drug relapse in individuals addicted to cocaine. This three-part study will evaluate the interaction between aripiprazole and cocaine. It will also determine the safety and effectiveness of aripiprazole in preventing drug relapse among cocaine addicts.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Craig Rush
• Collaborator: National Institute on Drug Abuse (NIDA)
• Treatments: Aripiprazole; Cocaine

Criteria

Inclusion Criteria:

• Meets DSM-IV diagnostic criteria for cocaine dependence

• Current cocaine use at study entry, as determined by a urine screen

• Body Mass Index of less than 30

• ECG results within normal limits

• If female, willing to use contraception throughout the study

Exclusion Criteria:

• Meets DSM-IV diagnostic criteria for dependence on any drugs other than cocaine or nicotine

• Currently seeking treatment for substance abuse

• Current or past serious illness, including impaired heart function, seizures, head trauma, or central nervous system tumors

• A family history of heart disease or seizures

• Current or past psychiatric disorder, other than substance abuse

• Pregnant