Currently there are no controlled data on the management of postpartum depression that fails
to respond to adequate antidepressant therapy. The investigators recently reported that a
large number of patients responded to the addition of atypical neuroleptics after having
failed antidepressant trials. Aripiprazole used adjunctively to antidepressants is effective
in patients with resistant depression but it has not been studied in patients with resistant
postpartum depression. The investigators propose to conduct a 6 week open-label study to
assess the effectiveness and tolerability of aripiprazole used adjunctively to
antidepressants in patients with resistant postpartum depression.