Aripiprazole Augmentation Therapy in Treatment-resistant Depression

• Status: Terminated
• Trial end date: 2009-11-01
• Target enrollment: 0
• Participant gender: All

Summary

20 therapy-refractory patients with major depression will be treated for 3 weeks with Aripiprazole 10 mg/d. Effectivity will be assessed using a pre-post comparison of different psychopathological rating scales and patient adherence.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital Freiburg
• Treatments: Aripiprazole

Criteria

Inclusion Criteria:

• major depression without psychotic features (DSM-IV definition)

• therapy resistance (two courses of antidepressants from different classes for more than 3 weeks in adequate dose)

• HAM-D score greater/equal than 17

• age 18-70

Exclusion Criteria:

• bipolar disorder

• active alcohol or illicit drug use

• female without effective contraception

• severe medical conditions

• psychotic features