Arginine + Citrulline as a Supplement for Weight Gain in Fetus With a Decrease in Their Growth Curve
Status:
Not yet recruiting
Trial end date:
2024-01-20
Target enrollment:
Participant gender:
Summary
Introduction:
The high incidence of intrauterine growth restriction is a public health problem; in this
pathology, newborns present weight below the 10th percentile, this implies an increase in
morbidity in the short term (complications due to hypoxia) and long term (pathologies typical
of Fetal Programming) as well as the cost of health services. L-arginine at different doses
has been used for some pathologies such as preeclampsia with controversial results. Authors
have mentioned that the joint administration of l-citrulline can increase the efficacy of
l-arginine. A stunted fetus is a challenge for the fetal physician; due to the complexity of
the follow-up, but above all to determine the moment for the termination of the pregnancy.
Finding some treatment to promote weight gain would improve the short- and long-term
expectations of these infants.
General objective To determine the efficacy of L-arginine + L-Citrulline (3 / 2g) every 24
hours, in fetuses with a decrease in their growth curve in the third trimester of pregnancy.
Material and methods Clinical trial, parallel, controlled, randomized simple, Double blind.
Two groups of pregnant women will be carried out in the third trimester; fetus with a
decrease in its growth curve, percentile> 10 and <25 for gestation age, they will be given an
informed consent letter and they will be randomized (double blind), they will proceed to give
intervention (L-arginine + Citrin (3 / 2 g) every 24 hours Vs placebo), a follow-up will be
carried out every two weeks, where the weight and growth curve will be calculated in
percentile, until the resolution of the pregnancy and data will be taken from the perinatal
results in both groups.
Statistic analysis Medics of central tendency will be calculated and Chi squared will be
applied for qualitative variables, T of student for qualitative variables and it is
considered P <0.005.