Overview

Arginase Inhibition in Ischemia-reperfusion Injury

Status:
Completed
Trial end date:
2013-09-01
Target enrollment:
0
Participant gender:
Male
Summary
The present project is designed to test the hypothesis that arginase contributes to endothelial dysfunction induced by ischemia-reperfusion in patients with coronary artery disease.
Phase:
Phase 1
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Karolinska Institutet
Criteria
Inclusion Criteria:

- Coronary artery disease

Exclusion Criteria:

- Age >80 years, Myocardial infarction/unstable angina within 6 weeks prior to the
study, Raynaud's phenomenon, peripheral vasculopathies, arterial shunting or other
vascular surgery of the study arm, Any concomitant disease or condition that may
interfere with the possibility for the patient to comply with or complete the study
protocol, Participant in an ongoing study, Unwillingness to participate following oral
and written information.