The objective of the study is to evaluate the safety and effectiveness of Arestin
(minocycline HCl) 1 mg Microspheres in the treatment of subjects with peri-implantitis, when
used in combination with mechanical debridement.
The hypothesis of the study is that Arestin in combination with mechanical debridement is
more effective in the treatment of peri-implantitis when compared to mechanical debridement
alone. The primary efficacy measure will be the reduction of probing depth at Day 180 as
measured at qualifying implant sites.