Aprepitant's Effect on Drug Metabolism in Multi-Day Combination (CHOP/R-CHOP) Chemotherapy Regimen in Lymphoma Patients
Status:
Completed
Trial end date:
2011-09-01
Target enrollment:
Participant gender:
Summary
The goal of this clinical research study is to learn the effect of combining aprepitant with
CHOP or R-CHOP in patients with Non-Hodgkin's Lymphoma (NHL) that is either newly diagnosed
or has come back. Researchers also want to see if aprepitant can help to prevent nausea
and/or vomiting that may be caused by chemotherapy treatment with CHOP or R-CHOP, in these
patients. CHOP consists of four drugs - Cyclophosphamide (also called Cytoxan/Neosar),
Doxorubicin (or Adriamycin), Vincristine (Oncovin) and Prednisolone while R-CHOP includes
Rituximab and CHOP.