Aprepitant for Postoperative Nausea and Vomiting in Laparoscopic Hysterectomy
Status:
Completed
Trial end date:
2010-09-01
Target enrollment:
Participant gender:
Summary
- Gynecological surgery is associated with a high incidence of postoperative nausea and
vomiting.
- NK1 receptor antagonists such as aprepitant appear to be highly effective for treating
acute and delayed emesis, and yet understanding of the efficacy of different doses of
aprepitant is limited.
- We performed a prospective, randomized, double-blinded placebo-controlled study of 123
female adults scheduled for laparoscopic hysterectomy who received 80 mg aprepitant, 125
mg aprepitant, or a placebo.
Phase:
N/A
Details
Lead Sponsor:
Gachon University Gil Medical Center
Collaborators:
Asan Medical Center University of California, San Francisco