Application of tPA in Suprachoroidal and Subretinal Hemorrhage
Status:
Recruiting
Trial end date:
2026-07-31
Target enrollment:
Participant gender:
Summary
Severe ocular rupture may be accompanied by suprachoroidal hemorrhage, or subretinal
hemorrhage, or with suprachoroidal hemorrhage and subretinal hemorrhage. The suprachoroidal
hemorrhage needs to be drained as soon as possible. In the process of waiting for the
spontaneous liquefaction of hemorrhage, uncontrollable elevated intraocular pressure may
occur, resulting in optic nerve injury, optic nerve atrophy, and visual loss. Tissue
plasminogen activator can promote the liquefaction of blood clots. Studies have found that
local application of tissue plasminogen activator in the suprachoroidal space can promote the
liquefaction of the hemorrhage. Local application of tissue fibrinogen activator under the
retina can promote the liquefaction of subretinal hemorrhage.
Phase:
N/A
Details
Lead Sponsor:
Second Affiliated Hospital, School of Medicine, Zhejiang University