Application of Vitamin E on Anal Fissure

• Status: Completed
• Trial end date: 2019-02-28
• Target enrollment: 0
• Participant gender: All

Summary

Patients were randomized into 2 groups:

• Vitamin E: Vitamin E ointment will be applied during 8 weeks

• Nitroglycerin: Nitroglycerin ointment will be applied during 8 weeks

Healing rate of chronic anal fissure in patients receiving Nitroglycerin ointment and subjects patients receiving Vitamin E ointment were evaluated .

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hospital General Universitario Elche
• Treatments: alpha-Tocopherol; Nitroglycerin; Tocopherols; Tocotrienols; Vitamin E; Vitamins

Criteria

Inclusion Criteria:

• Patients with diagnosis of chronic anal fissure

Exclusion Criteria:

• patients with associated anal pathologies

• intestinal inflammation disorders

• immunosuppression

• fissures secondary to underlying diseases (eg, AIDS, tuberculosis, or sexually transmitted diseases)

• patients with a history of headaches, heart disease, or intolerance to nitrates

• pregnant or lactating women

• patients with closed angle glaucoma