Application of Fecal Microbiota Transplantation in Children With ASD
Status:
Recruiting
Trial end date:
2023-09-01
Target enrollment:
Participant gender:
Summary
Autism Spectrum Disorder (ASD) is a group of serious neurodevelopmental disorders. Intestinal
microbial disturbance is common in children with ASD, and about 40% of ASD children suffer
from gastrointestinal dysfunction. A great deal of evidence shows that intestinal microbes
can influence the brain to play its role through "brain-intestinal-microbiota axis". Fecal
microbial biota transplantation (FMT) is the most direct way to change the intestinal flora
rapidly. We intend to study the difference of intestinal flora structure and metabolism
between ASD children and control children at the level of phylum, genus and species; To
explore the role of fecal bacteria transplantation in improving core symptoms and
gastrointestinal dysfunction of children in autism spectrum disorder; To study the potential
etiological mechanism of autism spectrum disorder.