Application of Amyloid PET in Cerebral Amyloid Angiopathy

• Status: Completed
• Trial end date: 2018-03-22
• Target enrollment: 0
• Participant gender: All

Summary

In this project, we will try to enhance the diagnostic potentials of amyloid PET in CAA by combination of dynamic amyloid PET with MRI SWI and MR perfusion images. We will also try to investigate the roles of CAA in patients with drug-related ICH and validate the accuracy of clinical CAA diagnostic criteria. In addition, we will try to study the characteristics of long-term progression of amyloid deposition in CAA patients. This project will enroll 100 patients with ICH, 30 patients with AD, and 30 control subjects. Each patient will receive the above image studies, followed by data analysis and comparison.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: National Taiwan University Hospital

Criteria

Inclusion Criteria:

• Age：above 20 years old with ICH or AD, or control subjects.

• Patient agrees to participate in the study and receive cerebral amyloid PET and MRI SWI and perfusion studies.

Exclusion Criteria:

• Patients could not receive the PET and MRI studies, including but not limited to poor cooperative agitation impeding adequate study, allergy to contrast medium, hemodynamic instability, implantation of cardiac pacemaker, past history of receiving aneurysm clipping, panic mood to MRI study.

• Patients with pregnancy or recently having a plan for pregnancy.

• Patient or family who does not agree to participate in the study.