Appendicectomy Versus Antibiotics in the Treatment of Acute Uncomplicated Appendicitis
Status:
Active, not recruiting
Trial end date:
2025-12-01
Target enrollment:
Participant gender:
Summary
Appendicectomy has been the treatment of acute appendicitis for over a hundred years.
Appendicectomy, however, includes operative and postoperative risks despite being a "routine"
operation. At the same time other similar intra-abdominal infections, such as diverticulitis,
are treated with antibiotics. There have been some encouraging reports on successful
treatment of appendicitis with antibiotics and it has been estimated that operative treatment
might be necessary for only 15 - 20 % of patients with acute appendicitis.
The aim of this randomized prospective study is to compare operative treatment (open
appendicectomy) with conservative treatment with antibiotics (ertapenem, Invanz). Before
randomization acute uncomplicated appendicitis is diagnosed with a CT scan.The hypothesis of
the study is that the majority of patients with uncomplicated acute appendicitis can be
treated successfully with antibiotics and unnecessary appendicectomies can be avoided.
Phase:
N/A
Details
Lead Sponsor:
Turku University Hospital
Collaborators:
Jyväskylä Central Hospital Mikkeli Central Hospital Oulu University Hospital Seinajoki Central Hospital Tampere University Hospital