Overview

Appaconitine Patch for Oral Mucositis Pain Caused by Chemoradiotherapy in Patients With Nasopharyngeal Cancer

Status:
Unknown status
Trial end date:
2019-01-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this clinical study is to evaluate the efficacy of lappaconitine adhesive patch in alleviation radiation induced mucositis pain and the improvements in QOL of patients with nasopharyngeal carcinoma . To determine if lappaconitine administered prior to radiation therapy reduces the severity of radiation induced oral mucositis pain in patients who have been diagnosed with nasopharyngeal carcinoma.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Fujian Cancer Hospital
Treatments:
Aconitine
Lappaconitine
Criteria
Inclusion Criteria:

- Newly histologic diagnosis of nasopharyngeal carcinoma without distant metastasis

- Clinical stage III~IVa( UICC (Union International Against Cancer) /AJCC (American
Joint Committee on Cancer) TNM staging system 8th edition)

- Karnofsky Performance Status Scale between 60-100

- WBC count ≥ 4×109/L,neutrophil differential count≥ 1.5×109/L,Hemoglobin ≥ 90g/L,
platelet count ≥ 100×109/L

- ALT or AST ≤2.5×ULN,bilirubin ≤2.5×ULN,Serum creatinine ≤1.5×ULN or Serum creatinine
clearance≥60ml/min

- Sign the informed consent.

Exclusion Criteria:

- Younger than 18 years old or older than 70 years old

- Pregnancy or lactation

- Severe cerebrovascular disease/canker/psychosis/uncontrolled diabetes

- Have suffered from other tumor or now suffering from other tumor

- Have suffered from oral diseases or salivary gland diseases or mow suffering from oral
diseases or salivary gland diseases

- Refuse to give up smoking/drinking/betel chewing

- suffering from other active infection diseases and in need of treatment.