Overview

Apoptotic Signaling Pathways in Rats With Endometrial Hyperplasia

Status:
Completed
Trial end date:
2015-03-01
Target enrollment:
0
Participant gender:
Female
Summary
The purpose of the study is to determine apoptotic signaling pathways such as Survivin, Bcl-2, Bax, c-Myc and caspase-9 expression levels in rats model with iatrogenic endometrial hyperplasia after metformin and medroxyprogesterone acetate administration.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Kayseri Education and Research Hospital
Treatments:
Estradiol
Estradiol 17 beta-cypionate
Estradiol 3-benzoate
Estradiol valerate
Medroxyprogesterone
Medroxyprogesterone Acetate
Metformin
Polyestradiol phosphate
Criteria
Inclusion criteria:

Forty-eight weeks old female Wistar-Albino rats, weighting between 180 and 260 g

Exclusion criteria.

We have no exclusion criteria because we examine drugs effects in the experimental rats