Antiviral Efficacy of the Combination Treatment With Poly IC and Entecavir for Chronic Hepatitis B

• Status: Unknown status
• Trial end date: 2017-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to investigate antiviral efficacy of the combination treatment with Poly IC and Entecavir and compare with the efficacy of Entecavir mono-therapy for chronic hepatitis B.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Wuhan Union Hospital, China
• Treatments: Antiviral Agents; Entecavir; Poly I-C

Criteria

Inclusion Criteria:

• HBsAg positive for more than 6 months.

• Having been treated wit Entecavir and the level of HBV DNA is under 1000 copies/ml.

• ALT ≤10×ULN， TB <2ULN .

Exclusion Criteria:

• Previous antiviral treatment for HBV.

• Co infection of HIV, HCV, HEV, HAV, or HAV.

• Evidence of hepatic carcinoma.

• Evidence of autoimmune disease.

• Evidence of thyroid disease.

• History of mental sickness.