Antithyroid Drug Treatment of Thyrotoxicosis in Young People

• Status: Completed
• Trial end date: 2015-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators aim to establish whether biochemical control during anti-thyroid drug therapy in young people with thyrotoxicosis varies depending upon whether a 'block and replace' or 'dose titration' regimen is used. The investigators will also assess remission rates and the frequency of side-effects in the two treatment groups.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Newcastle-upon-Tyne Hospitals NHS Trust
• Treatments: Carbimazole; Hormones; Propylthiouracil

Criteria

Inclusion Criteria:

1. All patients with thyrotoxicosis aged between 2 and 16 years at the time of diagnosis. Thyrotoxicosis will be diagnosed by the paediatrician on the basis of the clinical picture and the biochemistry (suppressed TSH with high thyroid hormone levels).

2. Child has consented/assented or consent via parent/guardian has been gained prior to any study specific procedures

Exclusion Criteria:

1. Known toxic adenoma / toxic hyperplasia (germline activating TSHR mutation).

2. McCune Albright Syndrome.

3. Previous episodes of Thyrotoxicosis..

4. Known allergic response to any of the study medication or ingredients as per SmPC.

5. Previous participation in this study.