Antithrombotic Treatment in Patients With Effectively Maintained Sinus Rhythm After Atrial Fibrillation Ablation

• Status: Terminated
• Trial end date: 2019-12-15
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to investigate the best strategy for long-term stroke prevention in patients who have sinus rhythm after a successful catheter ablation for atrial fibrillation (AF) and who are at risk of thromboembolic events (CHA2DS2-VASc score ≥2). The investigators are going to compare antiplatelet therapy to oral anticoagulation (OAC) with different doses of edoxaban (30mg and 60mg).

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Korea University Guro Hospital
• Treatments: Anticoagulants; Aspirin; Clopidogrel; Edoxaban

Criteria

Inclusion Criteria:

• Patients without evidence of any clinically apparent arrhythmia recurrence during at least six months after last catheter ablation of AF.

• Willing and able to provide informed consent

Exclusion Criteria:

• Patients who do not meet all of the above listed inclusion criteria.

• Patients with significant valvular heart disease or mechanical valve.

• Patients with hypertrophic cardiomyopathy.

• Patients with chronic renal impairment with creatinine clearance rate of < 30 mg/dl.

• Patients with contraindication to long-term OAC.

• Patients who had a stroke within one year prior to enrolment.