Antioxidant Use in Diabetes to Reduce Oxidative Stress
Status:
Active, not recruiting
Trial end date:
2024-06-02
Target enrollment:
Participant gender:
Summary
Dietary supplementation with antioxidant vitamins, such as Vitamin C and Vitamin E, reduces
malformation rates in embryos of diabetic animals. However, human trials exploring the
benefits of these antioxidant vitamins have produced unsatisfactory results in trials
designed to alleviating diabetic retinopathy, cardiovascular disease, and preeclampsia in
pregnancies. The investigators hypothesize that more potent, and better-targeted
antioxidants, such as N-acetylcysteine (NAC) and Polyunsaturated Fatty Acids(PUFA), will be
successful in preventing birth defects in the offspring of women with diabetes.
Phase:
Early Phase 1
Details
Lead Sponsor:
University of Maryland University of Maryland, Baltimore