Antinociceptive Modalities on Ischemia Reperfusion Injury
Status:
Completed
Trial end date:
2015-07-01
Target enrollment:
Participant gender:
Summary
Postoperative pain caused by surgery-associated tissue injury is a major concern for all the
clinical practitioners. Because it affects multiple systems and induces physiological,
immunological and psychological changes. Previous literature showed surgical injury induces a
systemic inflammatory metabolic-endocrine response that is proportional to the severity of
the surgical stress. In surgeries such as liver transplantation, the patients suffer not only
from postoperative pain but also an additional oxidative stress caused by ischemia
reperfusion. Previous report have proved that an adequate postoperative pain control improves
the recovery and reduces the inflammatory cascade by suppression of physiological and
psychological stresses. However, the effect of postoperative pain management on ischemia
reperfusion injury is unclear so far. In this three year study, we plan to continue our
previous study to test the following two hypothesis: (1) postoperative pain exacerbate remote
organ injury caused by ischemia reperfusion, (2) the interaction of different antinociceptive
modalities on ischemia reperfusion injury.