The Aim of this randoized controlled pilot study is to find a better treatment strategy for
active UC based on the recent knowledge regarding the microbiota in UC and the beneficial or
detrimental effects of antibiotics in restoring gut health and reducing inflammation. This
study is designed to determine whether therapy with two antibiotics during a flare -
amoxicillin and doxycillin, will be better than the current published antibiotic treatment
combination using these antibiotics with metronidazole ( as the latter which may degrade
beneficial species without adding benefit towards reducing pathobionts)