Antiinflammatoric and Antioxidative Effect of Melatonin in Human Endotoxaemia

• Status: Completed
• Trial end date: 2011-02-01
• Target enrollment: 0
• Participant gender: Male

Summary

This is a double blinded, randomised, crossover study with 12 healthy men between 18 and 40 year. The design is based on 6 days:

• day 1: On day time administration of LPS.

• day 2: On night time administration of LPS.

• day 3: On day time administration of LPS + Placebo.

• day 4: On day time administration of LPS + melatonin.

• day 5: On night time administration of LPS + placebo.

• day 6: On night time administration og LPS + melatonin.

Measuring the inflammatoric and oxidative response of LPS and the effect of melatonin compared to placebo on the endotoxaemia.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Herlev Hospital
• Treatments: Melatonin

Criteria

Inclusion Criteria:

• Men

• Age 18-49 year.

• Healthy

• No sleepiness disorders.

• No medication

• ASA I

Exclusion Criteria:

• Allergia to melatonin

• Women

• Smoking.

• Alcohol abuse.