Antiinflammatoric and Antioxidative Effect of Melatonin in Human Endotoxaemia
Status:
Completed
Trial end date:
2011-02-01
Target enrollment:
Participant gender:
Summary
This is a double blinded, randomised, crossover study with 12 healthy men between 18 and 40
year. The design is based on 6 days:
- day 1: On day time administration of LPS.
- day 2: On night time administration of LPS.
- day 3: On day time administration of LPS + Placebo.
- day 4: On day time administration of LPS + melatonin.
- day 5: On night time administration of LPS + placebo.
- day 6: On night time administration og LPS + melatonin.
Measuring the inflammatoric and oxidative response of LPS and the effect of melatonin
compared to placebo on the endotoxaemia.