Antiepileptic Drugs and Vascular Risk Markers

• Status: Terminated
• Trial end date: 2012-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine if certain seizure medications raise levels of cholesterol and other blood components which could increase the risk of heart attacks and strokes.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Thomas Jefferson University
• Collaborator: National Institute of Neurological Disorders and Stroke (NINDS)
• Treatments: Anticonvulsants; Etiracetam; Levetiracetam; Phenytoin; Piracetam; Valproic Acid

Criteria

Inclusion Criteria:

• Acute subarachnoid hemorrhage, Hunt-Hess Grades I-IV

• Within 48 hours of admission

Exclusion Criteria:

• Grade V subarachnoid hemorrhage

• Being treated with a lipid-lowering agent

• Contraindication to phenytoin, valproate, or levetiracetam (e.g. history of allergy to one of these agents)

• Contraindication to receiving no antiepileptic drug treatment (e.g. history of pre-existing epilepsy, seizure activity on admission EEG)