Antidepressant Medication Treatment for Depression in Individuals With Chronic Heart Failure

• Status: Completed
• Trial end date: 2008-09-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will examine the effect of antidepressant medication on rates of death and disease in depressed people with chronic heart failure.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Duke University
• Collaborator: National Institute of Mental Health (NIMH)
• Treatments: Sertraline

Criteria

Inclusion Criteria:

• Chronic heart failure

• Diagnostic and Statistical Manual- Fourth Edition (DSM-IV) criteria for major depression

• Current use of any antipsychotic medication at study entry

Exclusion Criteria:

• Life-threatening comorbidity with a 50% or higher likelihood of death within 1 year

• History of psychoses, bipolar disorder, or severe personality disorder

• History of alcohol or drug dependence in the last year

• Severe physical disability that may interfere with the study

• Neurological impairment

• Active suicidal ideations

• Current use of antidepressant medication(s) at the start of study medication