Antidepressant Medication Plus Donepezil for Treating Late-life Depression

• Status: Completed
• Trial end date: 2009-09-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will determine the effectiveness of combining escitalopram, venlafaxine, or duloxetine with donepezil, a medication used in Alzheimer's disease, in improving memory, concentration, attention, and problem solving abilities, and reducing the risk of depressive relapse in older individuals with depression.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Pittsburgh
• Collaborator: National Institute of Mental Health (NIMH)
• Treatments: Antidepressive Agents; Citalopram; Dexetimide; Donepezil; Duloxetine Hydrochloride; Venlafaxine Hydrochloride

Criteria

Inclusion Criteria:

• Current episode of major depression

• HRS-D 17-item score of 15 or higher

• Must be able to speak English

• Willing to discontinue other psychotropics

• Availability of family member/caregiver

• Hearing capacity adequate to respond to raised conversational voice

• Must have no formal diagnosis of dementia

Exclusion Criteria:

• Meets DSM-IV criteria for bipolar disorder, schizophrenia, schizoaffective disorder, or a psychotic disorders

• Alcohol/drug abuse within 12 months of study entry

• History of treatment non-adherence in other clinic protocols

• History of non-response to citalopram in other clinic protocols

• History of non-tolerance to SSRI therapy