Antidepressant Medication Plus Directly Observed Therapy for Improving Adherence to Antiretroviral Therapy

• Status: Completed
• Trial end date: 2006-08-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will evaluate the effectiveness of directly observed therapy plus antidepressant medication in improving adherence to antiretroviral drug therapy among HIV-infected homeless and marginally housed people with depression.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Massachusetts General Hospital
• Collaborator: National Institute of Mental Health (NIMH)
• Treatments: Antidepressive Agents; Fluoxetine

Criteria

Inclusion Criteria:

• Homeless or marginally housed

• Score of greater than 13 on the Beck Depression Inventory (BDI)

• DSM-IV diagnosis of major depressive disorder, dysthymia, or minor depressive disorder

• Considered by the reviewing psychiatrist to benefit from antidepressant therapy

• Willing to take antidepressant medication or, if currently taking medication, willing to change medications if deemed appropriate

• Consents to coordinate with the primary medical provider

• Speaks English

Exclusion Criteria:

• Signs and symptoms consistent with diagnosis of dementia, as defined by DSM-IV

• Current substance abuse disorder requiring immediate residential or inpatient treatment

• At risk for suicide

• Presence of signs and symptoms consistent with psychotic depression, as defined by DSM-IV, warranting immediate hospitalization

• Any condition or use of any medication that may make simultaneous use of antidepressant medication unsafe

• Currently prescribed antidepressant therapy and in psychiatric treatment (treated by a psychiatrist within 3 months prior to study entry)

• Pregnant

• Bipolar disorder

• Current psychotic disorder