Anticholinergic Premedication Induced Fever in Pediatric Ambulatory Anesthesia With Ketamine
Status:
Completed
Trial end date:
2014-12-01
Target enrollment:
Participant gender:
Summary
Anticholinergic drugs have traditionally been used for their antisialagogue properties. But
use of anticholinergic drugs can interfere with thermoregulation via inhibition of the
parasympathetically mediated sweat secretion. Sweating inhibition can reduce heat
elimination, and children's thermoregulation depend more on sweating than adults and they can
become hyperthermic when given these agents.
The investigators evaluated the fever-causing effects of adjunctive anticholinergics in
children under general anesthesia using ketamine.