Overview

Anticholinergic Deprescription in Schizophrenia

Status:
RECRUITING
Trial end date:
2029-06-30
Target enrollment:
Participant gender:
Summary
In this study, the investigators will examine whether a deprescription of unnecessary anticholinergic drugs (benztropine or trihexyphenidyl) can augment quality of life, functioning, and neurocognition in individuals who with schizophrenia. Individuals identified by clinical services who have unneeded prescriptions benztropine or trihexyphenidyl will be eligible for deprescription and study entry. Following a baseline evaluation and magnetic resonance imaging (MRI), participants will will be randomized to either staying on their anticholinergic drugs or undergoing deprescription per routine clinical care, and will undergo follow-up evaluations across 6 months. The investigators predict that reducing and deprescribing these drug, if clinically determined to be unnecessary will will enhance functioning, neurocognition
Phase:
PHASE4
Details
Lead Sponsor:
Deepak K. Sarpal, M.D.
Collaborator:
National Institute of Mental Health (NIMH)