Antibiotic Treatment Of Staphylococcus Aureus In Stable People With CF
Status:
Recruiting
Trial end date:
2025-06-30
Target enrollment:
Participant gender:
Summary
This is a randomized, double-blinded study that aims to assess the effect of an oral
antibiotic called Cephalexin (150 mg/kg/day) compared to placebo in clinically stable
children with cystic fibrosis who have grown a bacteria called MSSA (methicillin-susceptible
Staphylococcus aureus) over the course of 2 weeks.
A sensitive technique called MBW (multiple breath washout) will be used to look at how well
the participants lungs are functioning during the study and to see if the antibiotic improves
function. The primary outcome of the study will be the relative change in the MBW measurement
(LCI2.5) between day 0 and day 14 of study treatment.