Antibiotic Prophylaxis to Prevent Obesity-Related Induction Complications in Nulliparae at Term
Status:
Completed
Trial end date:
2021-06-01
Target enrollment:
Participant gender:
Summary
Obesity increases the risk of pregnancy complications, including among others puerperal
infections and cesarean delivery, and risk rises with increasing body mass index (BMI). Class
III obesity is an indication for delivery by 39 weeks, and these patients have a high rate of
labor induction. In nulliparous women from the general population (obese and non-obese),
labor induction at 39 weeks (compared to expectant management) is associated with less
morbidity and a lower cesarean rate. Antibiotic prophylaxis, standard before cesarean
delivery, is associated with less post-cesarean infection if azithromycin is added to the
standard cefazolin. In this placebo-controlled pilot trial, investigators will estimate the
parameters necessary to calculate the sample size for a planned multicenter clinical trial of
prophylactic antibiotics administered at the start of labor inductions of morbidly obese
nulliparous women at term.