Antibiotic Prophylaxis in Rectal Cancer Surgery: Oral With Intravenous Versus Intravenous Antibiotics.

• Status: Unknown status
• Trial end date: 2020-08-31
• Target enrollment: 0
• Participant gender: All

Summary

This is a randomized, controlled, parallel study to determine the efficiency of oral antibiotics in reduction of surgical site infection (SSI) in rectal cancer surgery.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: State Scientific Centre of Coloproctology, Russian Federation
• Treatments: Anti-Bacterial Agents; Antibiotics, Antitubercular; Cefoperazone; Erythromycin; Erythromycin Estolate; Erythromycin Ethylsuccinate; Erythromycin stearate; Metronidazole; Sulperazone

Criteria

Inclusion Criteria:

• Have a planned of resection of rectum

• Have signed approved informed consent form for the study.

Exclusion Criteria:

• Significant simultaneous surgical procedure (e.g., liver resection of metastasis)

• Bacterial infection at the time of surgery or antimicrobial therapy up to 4 weeks before surgery

• Preoperative severe impairment in renal function (creatinine clearance (MDRD) < 30 ml/min)

• Allergy on the study drugs .