Antibiotic Prophylaxis in Orthopaedic Traumatology
Status:
Completed
Trial end date:
2014-01-01
Target enrollment:
Participant gender:
Summary
It has been established that providing antibiotic prophylaxis after closed fracture fixation
with implants or prosthetic devices has beneficial effects. However, the optimal duration of
antibiotic prophylaxis after orthopaedic trauma surgery is not well-defined. Most studies
comparing single-dose prophylaxis with multiple-dose prophylaxis have not shown beneficial
effects of additional doses. Our proposed study is intended to further define the appropriate
duration of antibiotic (cefazolin) administration for surgical prophylaxis in the treatment
of closed fractures. We will randomly assigned patients into two groups, hopefully
differentiated only by the duration of antibiotic administration (single dose vs. 24 hours).
We will follow these patients until fracture healing and determine if there is a difference
in the incidence of infection.