Antibiotic Prophylaxis and Nausea and Vomiting in Cesarean Section Under Regional Anesthesia.
Status:
Recruiting
Trial end date:
2021-05-30
Target enrollment:
Participant gender:
Summary
The incidence of intraoperative nausea and vomiting in patients who undergo caesarean section
(C/S) under regional anesthesia is approximately 30-80%. Hypotension, pain, visceral
manipulation, fundal pressure, removal of the uterus during repair, intra-abdominal
irrigation, central neural opioids, intravenous oxytocin and antibiotics are possible risk
factors. Oxytocin and prophylactic antibiotics are administered simultaneously during C/S
operation, especially after the umbilical cord is clamped. Simultaneous administration of
drugs such as oxytocin and prophylactic antibiotics may induce nausea and vomiting after
umbilical cord clamping in the patient. In this study, it was aimed to investigate the effect
of prophylactic antibiotic administration 30 minutes before the incision and after cord
clamping on intraoperative nausea and vomiting in patients undergoing elective C/S under
regional anesthesia.
This study was planned to be carried out in Başkent University Zübeyde Hanım Research Center
Operating Room with 120 pregnant women (≥ 37 gestational weeks) undergoing elective C/S under
regional anesthesia in a prospective, randomized, double-blind manner.
Group 1 (Prophylactic antibiotic 30 minutes before skin incision): Antibiotic diluted in 10
ml syringe 30 minutes before skin incision and after cord clamping, 0.9% NaCl in 10 ml
syringe will be administered intravenously within 15 seconds.
Group 2 (prophylactic antibiotic after cord clamping): 30 minutes before the skin incision,
0.9% NaCl in a 10 ml injector and after the cord is clamped, the antibiotic diluted in a 10
ml syringe will be administered intravenously within 15 seconds.
Intraoperative nausea-retching-vomiting episodes (0 = No symptoms, 1: Nausea (uncomfortable
feeling with vomiting), 2: Gag (vomiting effort in which gastric contents cannot be
expelled), 3: Vomiting (Gastric contents are forced by mouth. ejection)] will be recorded.
Nausea scores will be evaluated on the verbal analog scale (VAS) with 11 points (0 = no
nausea, 10 = the most severe nausea). Before anesthesia, all patients will be informed about
the verbal analog scale (VAS) for nausea. VAS 1-3 = Mild Nausea, VAS 4-6 = Moderate nausea,
VAS 7-10 = Severe nausea. Evaluations will be made at certain time intervals.
Before CSEA application Time interval between CSEA application and fetus discharge Time
interval between fetus exit and expulsion of the uterus Time interval between expulsion of
the uterus and insertion into the abdomen Time interval between insertion of the uterus in
the abdomen and closing the fascia Time interval between fascia closure and skin closure Time
interval between skin closure and patient transport to the recovery unit
Nausea-retching-vomiting episodes, current systolic/diastolic blood pressure values,
nausea-vomiting scores, antiemetic and / or ephedrine requirement, amount of intravenous
fluid infused will be recorded.
Intraoperative prophylactic antibiotic use is considered as one of the possible causes of
intraoperative nausea and vomiting in patients who underwent cesarean section under regional
anesthesia. We believe that the results of our study can make contribution on both
intraoperative nausea-vomiting etiology in cases undergoing cesarean section under regional
anesthesia and the steps that can be taken to prevent it.