Overview

Antibiotic Prophylaxis After Simple Tooth Extraction in Immunosuppressed Patients With Autoimmune Rheumatic Diseases

Status:
NOT_YET_RECRUITING

Trial end date:
2029-02-10

Target enrollment:

Participant gender:

Summary

This randomized, double-blind, placebo-controlled clinical trial aims to evaluate whether single-dose amoxicillin prophylaxis administered prior to simple tooth extraction reduces postoperative infection rates in immunosuppressed patients with autoimmune rheumatic diseases (ARDs). Although antibiotic prophylaxis is not recommended for healthy individuals undergoing simple extractions, immunosuppressed ARD patients frequently receive antibiotics despite limited evidence supporting this practice. Secondary objectives include assessing infection severity, postoperative complications, and the impact of ARD diagnosis and immunosuppressive treatment on infection risk.

Phase:

PHASE4

Details

Lead Sponsor:

University of Sao Paulo General Hospital

Collaborator:

Fundao de Amparo Pesquisa do Estado de So Paulo

Treatments:

Amoxicillin