This study will provide us with clear information about the postoperative concentration of
antibiotic reached in synovial fluid, thereby helping surgeons to determine if concentration
could potentially prevent the growth and regrowth of common infecting microorganisms (based
on their MIC and MBEC). There is a need to define the actual benefit of antibiotic-loaded
bone cement, because the addition of antibiotic can reduce its mechanical strength. Moreover,
if sub-therapeutic antibiotic levels are achieved, this could facilitate the emergence of
resistant bacterial strains. Amidst the transition towards value-based care, our research
will enable surgeons to decide whether antibiotic-loaded cement is truly cost-effective in
the prevention of PJI.