Antibioprophylaxis for Excision-graft Surgery in Burn Patient (A2B-TRIAL)
Status:
Recruiting
Trial end date:
2025-01-09
Target enrollment:
Participant gender:
Summary
The indication of antibiotic prophylaxis in burn patients remains highly controversial and
hasn't reached a consensus. The objective of antibiotic prophylaxis would be to reduce the
risk of post-operative local and systemic infections. Burn surgery is associated with a high
risk of bacteremia and postoperative infections and sepsis. However, antibiotic prophylaxis
exposes to the risk of selecting drug-resistant pathogens as well as adverse effects of
antibiotics (i.e Clostridium difficile colitis).
Recommendations regarding perioperative prophylaxis using systemic antibiotics vary across
sources. The lack of data precludes any international strong recommendations regarding the
best strategy regarding antibiotic prophylaxis.
The goal of this project is therefore to determine whether peri-operative systemic
antibiotics prophylaxis could reduce the incidence of post-operative infections in burn
patients.