Overview

Anti-protozoal Effect of Steroid Hormone 20-hydroxyecdysone

Status:
Active, not recruiting
Trial end date:
2027-12-31
Target enrollment:
0
Participant gender:
Male
Summary
20-hydroxyecdysone is an ecdysteroid hormone found in invertebrates and plants. 20-hydroxyecdysone exhibits a broad range of biological properties in various in vitro and in vivo models, including anabolic, antioxidant, anti-inflammatory, immunomodulatory, anti-obesity and antidiabetic activities, in addition to acting as neuroprotective and hepatoprotective agent. Ecdysteroids are widely used by athletes as dietary supplements to increase strength and muscle mass during resistance training, to reduce fatigue and to ease recovery. Mhashilkar AS et al. (2016) were revealed anti-parasitic activity of 20-hydroxyecdysone against the human filarial parasites. According to recent searches in academic databases and medical search engines (Google, www.google.com; PubMed, www.ncbi.nlm.nih.gov/pubmed; and Medline, www.medline.com), no studies have been conducted to assess the anti-protozoal activity of 20-hydroxyecdysone. The aim of the study is to assess anti-protozoal activity of 20-hydroxyecdysone in water sports athletes with giardiasis.
Phase:
Phase 2/Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan
Treatments:
Metronidazole
Criteria
Inclusion Criteria:

- a presence of giardia lamblia in stool samples of partisipants

Exclusion Criteria:

- chronic and acute infectious diseases,

- endocrine diseases, congenital diseases,

- allergic dermatitis,

- bronchial asthma,

- allergic rhinitis and/or conjunctivitis,

- other skin disorders,

- history of using vitamin D supplements within three months ago, or use of any
medication influencing endocrine parameters.