Anti-protozoal Effect of Steroid Hormone 20-hydroxyecdysone
Status:
Active, not recruiting
Trial end date:
2027-12-31
Target enrollment:
Participant gender:
Summary
20-hydroxyecdysone is an ecdysteroid hormone found in invertebrates and plants.
20-hydroxyecdysone exhibits a broad range of biological properties in various in vitro and in
vivo models, including anabolic, antioxidant, anti-inflammatory, immunomodulatory,
anti-obesity and antidiabetic activities, in addition to acting as neuroprotective and
hepatoprotective agent. Ecdysteroids are widely used by athletes as dietary supplements to
increase strength and muscle mass during resistance training, to reduce fatigue and to ease
recovery. Mhashilkar AS et al. (2016) were revealed anti-parasitic activity of
20-hydroxyecdysone against the human filarial parasites. According to recent searches in
academic databases and medical search engines (Google, www.google.com; PubMed,
www.ncbi.nlm.nih.gov/pubmed; and Medline, www.medline.com), no studies have been conducted to
assess the anti-protozoal activity of 20-hydroxyecdysone.
The aim of the study is to assess anti-protozoal activity of 20-hydroxyecdysone in water
sports athletes with giardiasis.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan