Anti-inflmmation Treatment in Mood Disorder and Deep Learning Prediction Model
Status:
Recruiting
Trial end date:
2023-07-31
Target enrollment:
Participant gender:
Summary
This three-year study will enroll 180 patients with mood disorders (90 patients with major
depressive disorder and 90 patients with bipolar disorder) and high pro-inflammatory cytokine
levels. They will be randomly assigned to three groups of aspirin, statin and control groups
for 12 weeks according to the disease group. The first aim of the study is to compare the
efficacy of aspirin and statin in mood disorders. The second aim is to establish a
gene-immuno-brain imaging treatment prediction model by deep learning technology, using
pretreatment cytokines, neurocognitive function, brain structural/functional connectivity,
and telomere length as the predictors.